Product Data Sheet
9-Decyn-1-ol
Catalog No. A82324
9-Decyn-1-ol serves as an alkyl/ether-based linker in the synthesis of PROTACs, facilitating the conjugation of various compounds. It is central to the generation of INY-03-041 by linking GDC-0068 and Lenalidomide, resulting in a potent pan-Akt degrader that selectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. Additionally, 9-Decyn-1-ol features an alkyne group suitable for click chemistry applications, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, which is invaluable in chemical biology research.
Chemical Information
| Catalog Num | A82324 |
|---|---|
| M. Wt | 154.25 |
| Formula | C10H18O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 17643-36-6 |
| Synonyms | |
| SMILES | C#CCCCCCCCCO |
Biological Activity
| Description | 9-Decyn-1-ol serves as an alkyl/ether-based linker in the synthesis of PROTACs, facilitating the conjugation of various compounds. It is central to the generation of INY-03-041 by linking GDC-0068 and Lenalidomide, resulting in a potent pan-Akt degrader that selectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. Additionally, 9-Decyn-1-ol features an alkyne group suitable for click chemistry applications, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, which is invaluable in chemical biology research. |
|---|
RETURN POLICY
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
