Product Data Sheet
Tos-PEG4-t-butyl ester
Catalog No. A82373
Tos-PEG4-t-butyl ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs. This compound plays a critical role in the development of targeted protein degraders, facilitating the design of molecules such as BI-3663, which selectively degrades protein tyrosine kinase 2 (PTK2) via cereblon-mediated E3 ligase recruitment. BI-3663 demonstrates significant inhibitory activity against PTK2, with an IC50 value of 18 nM, making Tos-PEG4-t-butyl ester a valuable reagent for research in targeted protein degradation and therapeutic applications.
Chemical Information
| Catalog Num | A82373 |
|---|---|
| M. Wt | 432.53 |
| Formula | C20H32O8S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 217817-01-1 |
| Synonyms | Tos-PEG4-Boc |
| SMILES | O=C(OC(C)(C)C)CCOCCOCCOCCOS(=O)(C1=CC=C(C)C=C1)=O |
Biological Activity
| Description | Tos-PEG4-t-butyl ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs. This compound plays a critical role in the development of targeted protein degraders, facilitating the design of molecules such as BI-3663, which selectively degrades protein tyrosine kinase 2 (PTK2) via cereblon-mediated E3 ligase recruitment. BI-3663 demonstrates significant inhibitory activity against PTK2, with an IC50 value of 18 nM, making Tos-PEG4-t-butyl ester a valuable reagent for research in targeted protein degradation and therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
