Product Data Sheet
Methyltetrazine-Ph-PEG4-azide
Catalog No. A83592
Methyltetrazine-Ph-PEG4-azide is a PEG-based linker specifically designed for the synthesis of PROTACs, functioning as a vital component in targeted protein degradation strategies. This compound features a Tetrazine moiety that enables inverse electron-demand Diels-Alder reactions (iEDDA) with TCO-containing partners, enhancing the efficiency of linkage in complex biomolecular assemblies. Additionally, the azide functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This dual reactivity expands its utility in bioconjugation and chemical biology applications.
Chemical Information
| Catalog Num | A83592 |
|---|---|
| M. Wt | 389.41 |
| Formula | C17H23N7O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1802908-04-8 |
| Synonyms | |
| SMILES | CC1=NN=C(C2=CC=C(OCCOCCOCCOCCN=[N+]=[N-])C=C2)N=N1 |
Biological Activity
| Description | Methyltetrazine-Ph-PEG4-azide is a PEG-based linker specifically designed for the synthesis of PROTACs, functioning as a vital component in targeted protein degradation strategies. This compound features a Tetrazine moiety that enables inverse electron-demand Diels-Alder reactions (iEDDA) with TCO-containing partners, enhancing the efficiency of linkage in complex biomolecular assemblies. Additionally, the azide functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This dual reactivity expands its utility in bioconjugation and chemical biology applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
