Product Data Sheet
GDC-2992
Catalog No. A84534
GDC-2992 is an orally bioavailable PROTAC degrader targeting the androgen receptor (AR). With a DC50 of 2.7 nM for AR degradation and an IC50 of 9.7 nM for inhibiting cell proliferation in VCaP cells, GDC-2992 serves as a valuable tool in prostate cancer research. This compound facilitates investigations into the therapeutic potential of targeted protein degradation in androgen receptor-mediated signaling pathways.
Chemical Information
| Catalog Num | A84534 |
|---|---|
| M. Wt | 819.39 |
| Formula | C45H51ClN8O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2753651-10-2 |
| Synonyms | RO7656594 |
| SMILES | N#CC1=CC=C(O[C@H]2C(C)(C)[C@H](NC(C3=CC=C(N4CCC(CN5CCN(C6=CC(C=NN([C@@H]7C(NC(CC7)=O)=O)C8=O)=C8C=C6)CC5)CC4)C=C3)=O)C2(C)C)C=C1Cl |
Biological Activity
| Description | GDC-2992 is an orally bioavailable PROTAC degrader targeting the androgen receptor (AR). With a DC50 of 2.7 nM for AR degradation and an IC50 of 9.7 nM for inhibiting cell proliferation in VCaP cells, GDC-2992 serves as a valuable tool in prostate cancer research. This compound facilitates investigations into the therapeutic potential of targeted protein degradation in androgen receptor-mediated signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
