Product Data Sheet
ARD-2051
Catalog No. A84540
ARD-2051 is a selective and orally active degrader targeting the androgen receptor (AR) via a proteolysis-targeting chimera approach. It demonstrates potent DC50 values of 0.6 nM for AR degradation in prostate cancer cell lines such as LNCaP and VCaP. ARD-2051 exhibits significant anti-tumor efficacy in VCaP xenograft mouse models, making it a valuable tool for prostate cancer research and therapeutic exploration.
Chemical Information
| Catalog Num | A84540 |
|---|---|
| M. Wt | 789.32 |
| Formula | C43H45ClN8O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2632305-17-8 |
| Synonyms | |
| SMILES | O=C(C1=C2C=CC(N3CC(N4CCN(C(C5=CC=C(C=C5)N6CCC7(CC6)CN([C@H](C7)C)C8=CC(Cl)=C(C=C8)C#N)=O)CC4)C3)=C1)N(C2=O)C9C(NC(CC9)=O)=O |
Biological Activity
| Description | ARD-2051 is a selective and orally active degrader targeting the androgen receptor (AR) via a proteolysis-targeting chimera approach. It demonstrates potent DC50 values of 0.6 nM for AR degradation in prostate cancer cell lines such as LNCaP and VCaP. ARD-2051 exhibits significant anti-tumor efficacy in VCaP xenograft mouse models, making it a valuable tool for prostate cancer research and therapeutic exploration. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
