Product Data Sheet
AZ'3137
Catalog No. A84554
AZ'3137 is an orally bioavailable PROTAC-based degrader specifically targeting the androgen receptor (AR). It exhibits a DC50 value of 22 nM for AR degradation and efficiently degrades the L702H mutant variant with a DC50 of 92 nM. AZ'3137 demonstrates significant inhibition of LNCaP cell proliferation with a GI50 of 74 nM and effectively suppresses AR signaling and tumor growth in prostate cancer mouse models. This compound is suitable for studies investigating AR-targeted therapies in prostate cancer.
Chemical Information
| Catalog Num | A84554 |
|---|---|
| M. Wt | 801.87 |
| Formula | C43H47F4N7O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2960179-55-7 |
| Synonyms | |
| SMILES | COC1=CC(N2CCN(CC3CCN(C4=CC=C(C5CCN(C6=CC=C(C#N)C(C(F)(F)F)=C6F)CC5)C=C4)CC3)CC2)=CC7=C1C(N(C8CCC(NC8=O)=O)C7)=O |
Biological Activity
| Description | AZ'3137 is an orally bioavailable PROTAC-based degrader specifically targeting the androgen receptor (AR). It exhibits a DC50 value of 22 nM for AR degradation and efficiently degrades the L702H mutant variant with a DC50 of 92 nM. AZ'3137 demonstrates significant inhibition of LNCaP cell proliferation with a GI50 of 74 nM and effectively suppresses AR signaling and tumor growth in prostate cancer mouse models. This compound is suitable for studies investigating AR-targeted therapies in prostate cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
