Product Data Sheet
(S)-dHTC1
Catalog No. A84584
(S)-dHTC1 is a molecular glue degrader that targets the transcriptional co-activator ENL. This compound exhibits high-affinity binding to the E3 ligase upon forming the ENL:dHTC1 complex, with an IC50 value of 93 nM. In MV4;11 cells, (S)-dHTC1 effectively degrades ENL, demonstrating a DC50 value of 26 nM. This reagent is valuable for studying mechanisms in acute myeloid leukemia.
Chemical Information
| Catalog Num | A84584 |
|---|---|
| M. Wt | 676.79 |
| Formula | C33H40N8O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3081383-46-9 |
| Synonyms | |
| SMILES | O=C(NC1CCC1)C(C=C2)=CN(C2=N3)C=C3C4=CC=CC(C(NCCN5CCC(NS(=O)(N6C[C@@]7(CC(NC7=O)=O)CC6)=O)CC5)=O)=C4 |
Biological Activity
| Description | (S)-dHTC1 is a molecular glue degrader that targets the transcriptional co-activator ENL. This compound exhibits high-affinity binding to the E3 ligase upon forming the ENL:dHTC1 complex, with an IC50 value of 93 nM. In MV4;11 cells, (S)-dHTC1 effectively degrades ENL, demonstrating a DC50 value of 26 nM. This reagent is valuable for studying mechanisms in acute myeloid leukemia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
