Product Data Sheet
PROTAC ER Degrader-14
Catalog No. A84591
PROTAC ER Degrader-14 is a PTORAC-type degrader targeting the Estrogen Receptor (ER). This compound facilitates the degradation of ER through the recruitment of E3 ubiquitin ligase, effectively modulating estrogen signaling pathways. The specific design incorporates a linker derived from N-Boc-piperazine, combined with a ligand that binds to the target protein, enhancing selectivity and efficacy. It is applicable in studies focused on estrogen-related diseases, providing insights into cellular mechanisms and potential therapeutic interventions.
Chemical Information
| Catalog Num | A84591 |
|---|---|
| M. Wt | 743.86 |
| Formula | C44H46FN5O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2504911-73-1 |
| Synonyms | |
| SMILES | O=C1N([C@H](C(N2)=O)CCC2=O)CC3=C1C=CC(N4CCN(CC5CCN(C6=CC=C([C@H]7[C@@H](C8=CC=CC=C8)COC9=C7C=CC(O)=C9)C=C6F)CC5)CC4)=C3 |
Biological Activity
| Description | PROTAC ER Degrader-14 is a PTORAC-type degrader targeting the Estrogen Receptor (ER). This compound facilitates the degradation of ER through the recruitment of E3 ubiquitin ligase, effectively modulating estrogen signaling pathways. The specific design incorporates a linker derived from N-Boc-piperazine, combined with a ligand that binds to the target protein, enhancing selectivity and efficacy. It is applicable in studies focused on estrogen-related diseases, providing insights into cellular mechanisms and potential therapeutic interventions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
