Product Data Sheet
His-TERRα
Catalog No. A84620
His-TERRα is a targeted degrader designed for estrogen receptor-related alpha (ERRα) via the PROTAC mechanism. Utilizing a histidine residue as the E3 ligase ligand, it engages the N-end rule pathway to facilitate the degradation of ERRα, effectively diminishing its presence in cells. His-TERRα demonstrates potent inhibition of proliferation and migration in MCF7 breast cancer cells, making it a valuable tool for investigating breast cancer biology and therapeutic strategies.
Chemical Information
| Catalog Num | A84620 |
|---|---|
| M. Wt | 695.67 |
| Formula | C31H28F3N9O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2408835-49-2 |
| Synonyms | |
| SMILES | FC(F)(F)C(C=C(C=C1)C#N)=C1OC2=C(C=C(C=C2)/C=C3C(N(C(S\3)=O)CC4=CN(N=N4)CCCNC([C@@H](N)CC5=CN=CN5)=O)=O)OC |
Biological Activity
| Description | His-TERRα is a targeted degrader designed for estrogen receptor-related alpha (ERRα) via the PROTAC mechanism. Utilizing a histidine residue as the E3 ligase ligand, it engages the N-end rule pathway to facilitate the degradation of ERRα, effectively diminishing its presence in cells. His-TERRα demonstrates potent inhibition of proliferation and migration in MCF7 breast cancer cells, making it a valuable tool for investigating breast cancer biology and therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
