Product Data Sheet
Tamoxifen-PEG-Clozapine
Catalog No. A84622
Tamoxifen-PEG-Clozapine is an estrogen receptor α (ERα) PROTAC degrader that induces the degradation of ERα through the ubiquitin-proteasome pathway, utilizing the E3 ubiquitin ligase N-recognin 5. This compound presents significant potential for cancer research by modulating estrogen receptor signaling. Its unique design combines inhibition and degradation strategies, making it a valuable tool for studying ERα-related pathways and therapeutic interventions in estrogen-dependent cancers.
Chemical Information
| Catalog Num | A84622 |
|---|---|
| M. Wt | 943.57 |
| Formula | C54H63ClN6O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3104316-29-9 |
| Synonyms | |
| SMILES | CC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C(CCC(NCCOCCOCCOCCN3CCN(CC3)C4=NC5=CC(Cl)=CC=C5NC6=CC=CC=C64)=O)=O)C)/C7=CC=C(C=C7)O |
Biological Activity
| Description | Tamoxifen-PEG-Clozapine is an estrogen receptor α (ERα) PROTAC degrader that induces the degradation of ERα through the ubiquitin-proteasome pathway, utilizing the E3 ubiquitin ligase N-recognin 5. This compound presents significant potential for cancer research by modulating estrogen receptor signaling. Its unique design combines inhibition and degradation strategies, making it a valuable tool for studying ERα-related pathways and therapeutic interventions in estrogen-dependent cancers. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
