Product Data Sheet
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
Catalog No. A84634
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a compound designed for the synthesis of Protein Targeting Chimeras (PROTACs) targeting the PD-1/PD-L1 immune checkpoint. It features a ligand that facilitates binding to PD-1/PD-L1 and includes a PROTAC linker for degradation of target proteins. This compound can be utilized in the development of PROTAC PD-1/PD-L1 degrader-1, which effectively inhibits PD-1/PD-L1 interactions with an IC50 of 39.2 nM, making it a valuable tool for cancer immunotherapy research.
Chemical Information
| Catalog Num | A84634 |
|---|---|
| M. Wt | 780.18 |
| Formula | C41H45Cl3N4O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2691796-83-3 |
| Synonyms | |
| SMILES | N#CC1=CC=CC(COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(C=C2CN6CCCCC6C(N7CCNCC7)=O)Cl)=C1.Cl.Cl |
Biological Activity
| Description | BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a compound designed for the synthesis of Protein Targeting Chimeras (PROTACs) targeting the PD-1/PD-L1 immune checkpoint. It features a ligand that facilitates binding to PD-1/PD-L1 and includes a PROTAC linker for degradation of target proteins. This compound can be utilized in the development of PROTAC PD-1/PD-L1 degrader-1, which effectively inhibits PD-1/PD-L1 interactions with an IC50 of 39.2 nM, making it a valuable tool for cancer immunotherapy research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
