Product Data Sheet
Desmorpholinyl Quizartinib-PEG2-COOH
Catalog No. A84635
Desmorpholinyl Quizartinib-PEG2-COOH is a conjugate designed for targeted protein degradation, specifically targeting the FLT-3 receptor. This compound incorporates a FLT-3 ligand and a PEG-based PROTAC linker, facilitating the synthesis of PROTAC FLT-3 degrader 1, which effectively degrades FLT-3 internal tandem duplication (ITD) variants with an IC50 of 0.6 nM. This reagent is valuable for research applications focusing on targeted therapy and protein degradation mechanisms in hematological malignancies.
Chemical Information
| Catalog Num | A84635 |
|---|---|
| M. Wt | 607.68 |
| Formula | C30H33N5O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2292116-14-2 |
| Synonyms | |
| SMILES | O=C(O)CCOCCOCCOC1=CC=C2N3C(SC2=C1)=NC(C4=CC=C(NC(NC5=NOC(C(C)(C)C)=C5)=O)C=C4)=C3 |
Biological Activity
| Description | Desmorpholinyl Quizartinib-PEG2-COOH is a conjugate designed for targeted protein degradation, specifically targeting the FLT-3 receptor. This compound incorporates a FLT-3 ligand and a PEG-based PROTAC linker, facilitating the synthesis of PROTAC FLT-3 degrader 1, which effectively degrades FLT-3 internal tandem duplication (ITD) variants with an IC50 of 0.6 nM. This reagent is valuable for research applications focusing on targeted therapy and protein degradation mechanisms in hematological malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
