Product Data Sheet
K-Ras ligand-Linker Conjugate 3
Catalog No. A84638
K-Ras ligand-Linker Conjugate 3 is designed to selectively target K-Ras through its ligand, combined with a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This reagent is instrumental in the development of PROTAC-based degraders, particularly in the synthesis of PROTAC K-Ras Degrader-1, which demonstrates significant degradation efficacy of ≥70% in SW1573 cells. This compound is essential for research applications in targeted protein degradation and cancer therapeutics involving K-Ras.
Chemical Information
| Catalog Num | A84638 |
|---|---|
| M. Wt | 944.15 |
| Formula | C49H65N7O10S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2378261-87-9 |
| Synonyms | |
| SMILES | O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCOS(=O)(C7=CC=C(C)C=C7)=O)C6)=N2)CC1)OC(C)(C)C |
Biological Activity
| Description | K-Ras ligand-Linker Conjugate 3 is designed to selectively target K-Ras through its ligand, combined with a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This reagent is instrumental in the development of PROTAC-based degraders, particularly in the synthesis of PROTAC K-Ras Degrader-1, which demonstrates significant degradation efficacy of ≥70% in SW1573 cells. This compound is essential for research applications in targeted protein degradation and cancer therapeutics involving K-Ras. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
