Product Data Sheet
(Rac)-PROTAC PARP/EGFR ligand 1
Catalog No. A84640
(Rac)-PROTAC PARP/EGFR ligand 1 is a target protein ligand-linker conjugate that features ligands for both PARP and EGFR, along with a PROTAC linker to facilitate the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This reagent is instrumental in the advancement of targeted protein degradation strategies in research, enabling the synthesis of DP-C-4, a CRBN-based dual PROTAC designed for the simultaneous degradation of EGFR and PARP. Its application in drug discovery highlights its utility in elucidating the roles of these critical proteins in cancer biology.
Chemical Information
| Catalog Num | A84640 |
|---|---|
| M. Wt | 1020.52 |
| Formula | C53H56ClF2N9O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2935073-36-0 |
| Synonyms | |
| SMILES | O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCCCCNC(C(COCC#C)NC(CCCCCOC4=CC5=C(NC6=CC=C(C(Cl)=C6)F)N=CN=C5C=C4OC)=O)=O)=O)=O)=C2)F)C7=C1C=CC=C7 |
Biological Activity
| Description | (Rac)-PROTAC PARP/EGFR ligand 1 is a target protein ligand-linker conjugate that features ligands for both PARP and EGFR, along with a PROTAC linker to facilitate the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This reagent is instrumental in the advancement of targeted protein degradation strategies in research, enabling the synthesis of DP-C-4, a CRBN-based dual PROTAC designed for the simultaneous degradation of EGFR and PARP. Its application in drug discovery highlights its utility in elucidating the roles of these critical proteins in cancer biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
