Product Data Sheet
K-Ras ligand-Linker Conjugate 2
Catalog No. A84641
K-Ras ligand-Linker Conjugate 2 is designed to specifically target K-Ras by integrating a selective ligand with a PROTAC linker that facilitates the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This conjugate serves as a critical precursor for the synthesis of PROTAC K-Ras Degrader-1, demonstrating significant biological activity by achieving ≥70% degradation efficiency in SW1573 cancer cells. It is a valuable tool for research focused on protein degradation and therapeutic strategies for K-Ras-driven cancers.
Chemical Information
| Catalog Num | A84641 |
|---|---|
| M. Wt | 822.99 |
| Formula | C45H58N8O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2741300-61-6 |
| Synonyms | |
| SMILES | NCCOCCOCCOCCO[C@H]1CN(C)[C@H](COC2=NC3=C(CCN(C4=CC=CC5=C4C=CC=C5)C3)C(N6CCN(C(OCC7=CC=CC=C7)=O)[C@@H](CC#N)C6)=N2)C1 |
Biological Activity
| Description | K-Ras ligand-Linker Conjugate 2 is designed to specifically target K-Ras by integrating a selective ligand with a PROTAC linker that facilitates the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This conjugate serves as a critical precursor for the synthesis of PROTAC K-Ras Degrader-1, demonstrating significant biological activity by achieving ≥70% degradation efficiency in SW1573 cancer cells. It is a valuable tool for research focused on protein degradation and therapeutic strategies for K-Ras-driven cancers. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
