Product Data Sheet
K-Ras ligand-Linker Conjugate 4
Catalog No. A84644
K-Ras ligand-Linker Conjugate 4 functions as a targeted protein ligand-linker conjugate designed for K-Ras. This compound incorporates a ligand to effectively recruit K-Ras and a PROTAC linker that interacts with E3 ligases such as VHL, CRBN, MDM2, and IAP. It serves as a synthetic precursor for PROTAC K-Ras Degrader-1, demonstrating significant biological activity with at least 70% degradation efficacy in SW1573 cells. This conjugate is essential for research into targeted protein degradation and the modulation of K-Ras-related pathways.
Chemical Information
| Catalog Num | A84644 |
|---|---|
| M. Wt | 697.82 |
| Formula | C35H51N7O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2378261-83-5 |
| Synonyms | |
| SMILES | O=C(N1[C@@H](CC#N)CN(C2=C3C(CNCC3)=NC(OC[C@H]4N(C)C[C@H](OCCOCCOCCOCCO)C4)=N2)CC1)OCC5=CC=CC=C5 |
Biological Activity
| Description | K-Ras ligand-Linker Conjugate 4 functions as a targeted protein ligand-linker conjugate designed for K-Ras. This compound incorporates a ligand to effectively recruit K-Ras and a PROTAC linker that interacts with E3 ligases such as VHL, CRBN, MDM2, and IAP. It serves as a synthetic precursor for PROTAC K-Ras Degrader-1, demonstrating significant biological activity with at least 70% degradation efficacy in SW1573 cells. This conjugate is essential for research into targeted protein degradation and the modulation of K-Ras-related pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
