Product Data Sheet
KYL peptide
Catalog No. A84695
KYL peptide is an EphA4 antagonist that selectively inhibits the EphA4 receptor, demonstrating an IC50 of 4.22 μM and a Kd of 1.3 μM. By binding to the ligand-binding domain of EphA4, KYL peptide effectively mitigates Aβ-induced synaptic dysfunction and enhances synaptic plasticity in models of Alzheimer's disease. Additionally, this peptide may facilitate nerve regeneration following injury and has potential applications in modulating immune responses.
Chemical Information
| Catalog Num | A84695 |
|---|---|
| M. Wt | 1465.73 |
| Formula | C74H108N14O17 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 676657-00-4 |
| Synonyms | |
| SMILES | C([C@@H](C(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CO)=O)CO)=O)CC(C)C)=O)[C@H](C)C)=O)CCC1)NC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CCCCN)N)=O)=O)CC(C)C)=O)CCC2)CC4=CC=C(O)C=C4)=O)C=5C=6C(NC5)=CC=CC6 |
Biological Activity
| Description | KYL peptide is an EphA4 antagonist that selectively inhibits the EphA4 receptor, demonstrating an IC50 of 4.22 μM and a Kd of 1.3 μM. By binding to the ligand-binding domain of EphA4, KYL peptide effectively mitigates Aβ-induced synaptic dysfunction and enhances synaptic plasticity in models of Alzheimer's disease. Additionally, this peptide may facilitate nerve regeneration following injury and has potential applications in modulating immune responses. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
