Product Data Sheet
LDN-211904
Catalog No. A84702
LDN-211904 is a potent and reversible inhibitor of EphB3, with an IC50 of 79 nM, making it a valuable tool for studying EphB3-mediated signaling pathways. It demonstrates good metabolic stability in mouse liver microsomes, indicating its potential for in vivo applications. In research contexts, LDN-211904 may synergize with cetuximab to effectively inhibit STAT3 activation and address colorectal cancer stemness, as well as resistance mechanisms associated with cetuximab treatment.
Chemical Information
| Catalog Num | A84702 |
|---|---|
| M. Wt | 354.83 |
| Formula | C19H19ClN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1198408-39-7 |
| Synonyms | |
| SMILES | O=C(C1=CN=C2C=CC(C3CCNCC3)=CN21)NC4=C(Cl)C=CC=C4 |
Biological Activity
| Description | LDN-211904 is a potent and reversible inhibitor of EphB3, with an IC50 of 79 nM, making it a valuable tool for studying EphB3-mediated signaling pathways. It demonstrates good metabolic stability in mouse liver microsomes, indicating its potential for in vivo applications. In research contexts, LDN-211904 may synergize with cetuximab to effectively inhibit STAT3 activation and address colorectal cancer stemness, as well as resistance mechanisms associated with cetuximab treatment. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
