Product Data Sheet
ITK/TRKA-IN-1
Catalog No. A84716
ITK/TRKA-IN-1 is a selective inhibitor targeting IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA), exhibiting an IC50 of 1.0 nM for ITK and achieving 96% inhibition of TRKA. This compound is valuable for investigating the roles of ITK and TRKA in immune responses and neurobiology. Its dual inhibitory action positions it as a significant tool for research in cancer immunotherapy and neurodegenerative disease studies, enabling the exploration of signaling pathways associated with these kinases.
Chemical Information
| Catalog Num | A84716 |
|---|---|
| M. Wt | 484.54 |
| Formula | C25H30F2N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2655557-54-1 |
| Synonyms | |
| SMILES | C[C@@]12CC3=C(C(C4=NC5=C(N4)C=C(C(N(C([C@@H](N6CCOCC6)C)=O)C)=C5)C)=NN3)C[C@@H]1C2(F)F |
Biological Activity
| Description | ITK/TRKA-IN-1 is a selective inhibitor targeting IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA), exhibiting an IC50 of 1.0 nM for ITK and achieving 96% inhibition of TRKA. This compound is valuable for investigating the roles of ITK and TRKA in immune responses and neurobiology. Its dual inhibitory action positions it as a significant tool for research in cancer immunotherapy and neurodegenerative disease studies, enabling the exploration of signaling pathways associated with these kinases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
