Product Data Sheet
MRL-SYKi
Catalog No. A84722
MRL-SYKi is a selective chemical probe targeting spleen tyrosine kinase (SYK). It demonstrates potent binding to gain-of-function variants of SYK, with IC50 values of 2.1 nM for SYK(S550Y), 14 nM for SYK(S550F), and 4.6 nM for SYK(P342T) in digitonin-permeabilized cell assays. MRL-SYKi effectively inhibits catalytic activity, achieving IC50 values of 63 nM and 95 nM for SYK(S550F) and SYK(P342T) respectively in phospho-specific assays. This compound is valuable for advancing research on inflammation and related signaling pathways.
Chemical Information
| Catalog Num | A84722 |
|---|---|
| M. Wt | 452.57 |
| Formula | C24H28N4O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1312534-69-2 |
| Synonyms | |
| SMILES | O[C@@]1(C2=NC=C(C3=CC(NC4=NC=CC(C)=N4)=CC(C)=C3)S2)CC(C)([C@H](CC1)C(O)=O)C |
Biological Activity
| Description | MRL-SYKi is a selective chemical probe targeting spleen tyrosine kinase (SYK). It demonstrates potent binding to gain-of-function variants of SYK, with IC50 values of 2.1 nM for SYK(S550Y), 14 nM for SYK(S550F), and 4.6 nM for SYK(P342T) in digitonin-permeabilized cell assays. MRL-SYKi effectively inhibits catalytic activity, achieving IC50 values of 63 nM and 95 nM for SYK(S550F) and SYK(P342T) respectively in phospho-specific assays. This compound is valuable for advancing research on inflammation and related signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
