Product Data Sheet
TAM-IN-1
Catalog No. A84748
TAM-IN-1 is a potent macrocyclic inhibitor targeting TAM receptors Axl and Mer, displaying binding affinities with Kis of 130 pM and <50 pM, respectively. This compound demonstrates significant biological activity in modulating pathways associated with tumor progression and immune evasion. TAM-IN-1 is applicable in research focused on cancer therapeutics and the study of receptor-mediated signaling in the tumor microenvironment.
Chemical Information
| Catalog Num | A84748 |
|---|---|
| M. Wt | 460.89 |
| Formula | C21H22ClFN6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1454847-05-2 |
| Synonyms | |
| SMILES | OCCN1C2=C(C(C)=N1)C3=CN=C(N)C(O[C@@H](C4=C(Cl)C(F)=CC=C4C(N(C2)C)=O)C)=N3 |
Biological Activity
| Description | TAM-IN-1 is a potent macrocyclic inhibitor targeting TAM receptors Axl and Mer, displaying binding affinities with Kis of 130 pM and <50 pM, respectively. This compound demonstrates significant biological activity in modulating pathways associated with tumor progression and immune evasion. TAM-IN-1 is applicable in research focused on cancer therapeutics and the study of receptor-mediated signaling in the tumor microenvironment. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
