Product Data Sheet
UNC9426
Catalog No. A84749
UNC9426 is a highly selective inhibitor of TYRO3, exhibiting an IC50 of 2.1 nM and demonstrating 276-fold and 90-fold selectivity over MERTK and AXL, respectively. This compound effectively reduces platelet aggregation without prolonging bleeding time, and it inhibits TYRO3-mediated processes in both tumor cells and macrophages. With a favorable safety profile, UNC9426 is an invaluable tool for investigating TYRO3-dependent phenotypes, including applications in non-small cell lung cancer (NSCLC) research.
Chemical Information
| Catalog Num | A84749 |
|---|---|
| M. Wt | 632.64 |
| Formula | C32H34F6N6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3051784-94-9 |
| Synonyms | |
| SMILES | O[C@H](CC1)CC[C@@H]1N2C=C(C3=CC=C(C=C3)CN4CCN(CC4)C)C5=CN=C(N=C52)NC6=CC(C(F)(F)F)=CC(C(F)(F)F)=C6 |
Biological Activity
| Description | UNC9426 is a highly selective inhibitor of TYRO3, exhibiting an IC50 of 2.1 nM and demonstrating 276-fold and 90-fold selectivity over MERTK and AXL, respectively. This compound effectively reduces platelet aggregation without prolonging bleeding time, and it inhibits TYRO3-mediated processes in both tumor cells and macrophages. With a favorable safety profile, UNC9426 is an invaluable tool for investigating TYRO3-dependent phenotypes, including applications in non-small cell lung cancer (NSCLC) research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
