Product Data Sheet
CDD-1431
Catalog No. A84896
CDD-1431 is a selective inhibitor of Bone Morphogenetic Protein Receptor 2 (BMPR2), exhibiting a Kiapp value of 20.6 nM. This compound effectively suppresses BMP-responsive element (BRE)-reporter activity, with an IC50 of 4.87 μM, demonstrating its potency in modulating BMP signaling pathways. BMPR2 plays a crucial role in various cellular processes across multiple tissues, including the kidney, skeletal muscle, heart, and reproductive organs, and its inhibition can provide insights into mechanisms underlying ectopic bone formation and related pathologies.
Chemical Information
| Catalog Num | A84896 |
|---|---|
| M. Wt | 658.77 |
| Formula | C33H38N8O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3034216-31-1 |
| Synonyms | |
| SMILES | COC(C=N1)=C(N2CCN(C3=CC=CC(CNC(C4=CC=C(CCC(NC)=O)C=C4)=O)=C3)CC2)N=C1NC5=CC(S(=O)(N)=O)=CC=C5 |
Biological Activity
| Description | CDD-1431 is a selective inhibitor of Bone Morphogenetic Protein Receptor 2 (BMPR2), exhibiting a Kiapp value of 20.6 nM. This compound effectively suppresses BMP-responsive element (BRE)-reporter activity, with an IC50 of 4.87 μM, demonstrating its potency in modulating BMP signaling pathways. BMPR2 plays a crucial role in various cellular processes across multiple tissues, including the kidney, skeletal muscle, heart, and reproductive organs, and its inhibition can provide insights into mechanisms underlying ectopic bone formation and related pathologies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
