Product Data Sheet
TJN-331
Catalog No. A84911
TJN-331 is a potent, orally active inhibitor of TGF-β1, targeting the TGF-β signaling pathway. This compound demonstrates significant therapeutic potential by ameliorating anti-glomerular basement membrane nephritis in rat models, reducing extracapillary proliferation in glomeruli. Additionally, TJN-331 inhibits mesangial expansion in experimental IgA nephropathy in ddY mice, making it a valuable tool for researching nephritis and IgA nephropathy.
Chemical Information
| Catalog Num | A84911 |
|---|---|
| M. Wt | 326.39 |
| Formula | C19H22N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 219964-53-1 |
| Synonyms | |
| SMILES | O=C(/C=C/C1=CN=CC=C1)N(C)CCC2=CC(OC)=C(C=C2)OC |
Biological Activity
| Description | TJN-331 is a potent, orally active inhibitor of TGF-β1, targeting the TGF-β signaling pathway. This compound demonstrates significant therapeutic potential by ameliorating anti-glomerular basement membrane nephritis in rat models, reducing extracapillary proliferation in glomeruli. Additionally, TJN-331 inhibits mesangial expansion in experimental IgA nephropathy in ddY mice, making it a valuable tool for researching nephritis and IgA nephropathy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
