Product Data Sheet
11-Ketodihydrotestosterone
Catalog No. A84920
11-Ketodihydrotestosterone (11-KDHT) is a potent androgen receptor (AR) agonist, exhibiting a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. This endogenous steroid, a metabolite of 11β-Hydroxyandrostenedione, plays a significant role in regulating gene expression, protein synthesis, and cellular growth, particularly in androgen-dependent prostate cancer cells. Its ability to activate AR makes it valuable for research into androgen signaling pathways and the development of therapeutic strategies for prostate cancer.
Chemical Information
| Catalog Num | A84920 |
|---|---|
| M. Wt | 304.42 |
| Formula | C19H28O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 32694-37-4 |
| Synonyms | 11-KDHT; 5α-Dihydro-11-keto testosterone |
| SMILES | C[C@@]1(C2)[C@@H](O)CC[C@@]1([H])[C@]3([H])CC[C@@]4([H])CC(CC[C@]4(C)[C@@]3([H])C2=O)=O |
Biological Activity
| Description | 11-Ketodihydrotestosterone (11-KDHT) is a potent androgen receptor (AR) agonist, exhibiting a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. This endogenous steroid, a metabolite of 11β-Hydroxyandrostenedione, plays a significant role in regulating gene expression, protein synthesis, and cellular growth, particularly in androgen-dependent prostate cancer cells. Its ability to activate AR makes it valuable for research into androgen signaling pathways and the development of therapeutic strategies for prostate cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
