Product Data Sheet
WCA-814
Catalog No. A84980
WCA-814 is a conjugate that functions as an androgen receptor (AR) antagonist and Hsp90 inhibitor. This compound effectively induces degradation of full-length androgen receptors as well as the AR-V7 variant. WCA-814 demonstrates notable cytotoxicity in prostate cancer cells, with an IC50 of 171.2 nM, and 26.5 nM and 22 nM for LNCaP and 22Rv1 cell lines, respectively. This makes it a valuable tool for research in prostate cancer therapeutics and underlying mechanisms of androgen receptor signaling.
Chemical Information
| Catalog Num | A84980 |
|---|---|
| M. Wt | 861.43 |
| Formula | C46H53ClN10O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2951858-45-8 |
| Synonyms | |
| SMILES | CC(C1=C(C=C(C(C2=NNC(N2C3=CC=C(C=C3)CN4CCN(CC4)CC5CCN(CC5)C6=CC=C(N=N6)C(N[C@H]7CC[C@@H](CC7)OC8=CC(Cl)=C(C=C8)C#N)=O)=O)=C1)O)O)C |
Biological Activity
| Description | WCA-814 is a conjugate that functions as an androgen receptor (AR) antagonist and Hsp90 inhibitor. This compound effectively induces degradation of full-length androgen receptors as well as the AR-V7 variant. WCA-814 demonstrates notable cytotoxicity in prostate cancer cells, with an IC50 of 171.2 nM, and 26.5 nM and 22 nM for LNCaP and 22Rv1 cell lines, respectively. This makes it a valuable tool for research in prostate cancer therapeutics and underlying mechanisms of androgen receptor signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
