Product Data Sheet
AR antagonist 10
Catalog No. A85007
AR Antagonist 10 is a potent androgen receptor (AR) antagonist that demonstrates an IC50 value of 0.04 μM. It employs dual mechanisms of action by disrupting AR dimerization and promoting AR degradation through the ubiquitin-proteasome pathway. This compound shows significant efficacy against drug-resistant AR variants and effectively inhibits tumor growth in LNCaP xenograft models. AR Antagonist 10 has potential applications in the treatment of drug-resistant prostate cancer.
Chemical Information
| Catalog Num | A85007 |
|---|---|
| M. Wt | 404.87 |
| Formula | C18H17ClN4O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3068489-78-8 |
| Synonyms | |
| SMILES | O=C(C1=CC2=C(OC=C1)C=CC(Cl)=C2)NC3=NC(CN4CCOCC4)=NS3 |
Biological Activity
| Description | AR Antagonist 10 is a potent androgen receptor (AR) antagonist that demonstrates an IC50 value of 0.04 μM. It employs dual mechanisms of action by disrupting AR dimerization and promoting AR degradation through the ubiquitin-proteasome pathway. This compound shows significant efficacy against drug-resistant AR variants and effectively inhibits tumor growth in LNCaP xenograft models. AR Antagonist 10 has potential applications in the treatment of drug-resistant prostate cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
