Product Data Sheet
AR antagonist 12
Catalog No. A85008
AR Antagonist 12 is a potent androgen receptor (AR) antagonist that selectively targets wild-type AR and the AR-F877L variant, demonstrating IC50 values of 119.3 μM and 98.2 μM, respectively. This compound effectively reduces the protein levels of AR, AR-V7, and PSA in a dose-dependent and time-dependent manner, showcasing its therapeutic potential. AR Antagonist 12 is particularly useful for investigating resistance mechanisms in prostate cancer, including studies related to Enzalutamide responsiveness.
Chemical Information
| Catalog Num | A85008 |
|---|---|
| M. Wt | 484.47 |
| Formula | C24H23F3N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2902679-42-7 |
| Synonyms | |
| SMILES | O=C(NC1=CN=C(C(C(F)(F)F)=C1)C#N)[C@@](O)(CN2CC3CCC(N3C4=CC=C(C=C4)C#N)C2)C |
Biological Activity
| Description | AR Antagonist 12 is a potent androgen receptor (AR) antagonist that selectively targets wild-type AR and the AR-F877L variant, demonstrating IC50 values of 119.3 μM and 98.2 μM, respectively. This compound effectively reduces the protein levels of AR, AR-V7, and PSA in a dose-dependent and time-dependent manner, showcasing its therapeutic potential. AR Antagonist 12 is particularly useful for investigating resistance mechanisms in prostate cancer, including studies related to Enzalutamide responsiveness. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
