Product Data Sheet
Androgen receptor antagonist 12
Catalog No. A85015
Androgen Receptor Antagonist 12 is a potent orally active antagonist of the androgen receptor, exhibiting an IC50 of 0.30 μM. It effectively inhibits the transcriptional activity of variant androgen receptor mutants and suppresses the proliferation of androgen receptor-positive prostate cancer cell lines. Additionally, this compound obstructs androgen receptor nuclear translocation and demonstrates tumor growth inhibition in a C4-2B xenograft mouse model. Androgen Receptor Antagonist 12 is a valuable tool for research in prostate cancer biology.
Chemical Information
| Catalog Num | A85015 |
|---|---|
| M. Wt | 283.21 |
| Formula | C12H8F3N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 6605-17-0 |
| Synonyms | |
| SMILES | FC(C1=CC(NC2=NC=C([N+]([O-])=O)C=C2)=CC=C1)(F)F |
Biological Activity
| Description | Androgen Receptor Antagonist 12 is a potent orally active antagonist of the androgen receptor, exhibiting an IC50 of 0.30 μM. It effectively inhibits the transcriptional activity of variant androgen receptor mutants and suppresses the proliferation of androgen receptor-positive prostate cancer cell lines. Additionally, this compound obstructs androgen receptor nuclear translocation and demonstrates tumor growth inhibition in a C4-2B xenograft mouse model. Androgen Receptor Antagonist 12 is a valuable tool for research in prostate cancer biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
