Product Data Sheet
YM580
Catalog No. A85019
YM580 is a selective antagonist of the Androgen Receptor (AR), exhibiting potent activity with an IC50 of 0.11 μM and Ki values of 4.6 nM for human AR and 6.2 nM for rat AR. It demonstrates high selectivity over other steroid hormone receptors, including PR, GR, and ERα, with Kis greater than 3300 nM. In vivo studies show that YM580 effectively reduces ventral prostate weight in mature intact rats in a dose-dependent manner while maintaining serum testosterone levels. This compound is valuable for research into prostate cancer and androgen-related pathways.
Chemical Information
| Catalog Num | A85019 |
|---|---|
| M. Wt | 471.41 |
| Formula | C21H19F6N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 262295-11-4 |
| Synonyms | |
| SMILES | C[C@@H]1N(C2=CC(C(F)(F)F)=C(C#N)C=C2)C[C@@H](C)N(C(NC=3C=CC(C(F)(F)F)=NC3)=O)C1 |
Biological Activity
| Description | YM580 is a selective antagonist of the Androgen Receptor (AR), exhibiting potent activity with an IC50 of 0.11 μM and Ki values of 4.6 nM for human AR and 6.2 nM for rat AR. It demonstrates high selectivity over other steroid hormone receptors, including PR, GR, and ERα, with Kis greater than 3300 nM. In vivo studies show that YM580 effectively reduces ventral prostate weight in mature intact rats in a dose-dependent manner while maintaining serum testosterone levels. This compound is valuable for research into prostate cancer and androgen-related pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
