Product Data Sheet
AR antagonist 17
Catalog No. A85040
AR Antagonist 17 is a potent, selective androgen receptor (AR) antagonist, exhibiting an IC50 value of 0.010 μM. This compound effectively inhibits AR dimerization and nuclear translocation, demonstrating significant efficacy in castration-resistant prostate cancer (CRPC) cell lines, including those with drug-resistant AR mutations. In preclinical models, AR Antagonist 17 has shown the ability to suppress tumor growth in LNCaP xenografts without noticeable toxicity. This reagent serves as a valuable tool for investigations into CRPC mechanisms and potential therapeutic strategies.
Chemical Information
| Catalog Num | A85040 |
|---|---|
| M. Wt | 499.53 |
| Formula | C21H20F3N3O4S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3064715-04-1 |
| Synonyms | |
| SMILES | CC1=C(C=C(O1)C2=CC=CC(C(F)(F)F)=C2)C(NC3=NC(CN4CCS(=O)(CC4)=O)=CS3)=O |
Biological Activity
| Description | AR Antagonist 17 is a potent, selective androgen receptor (AR) antagonist, exhibiting an IC50 value of 0.010 μM. This compound effectively inhibits AR dimerization and nuclear translocation, demonstrating significant efficacy in castration-resistant prostate cancer (CRPC) cell lines, including those with drug-resistant AR mutations. In preclinical models, AR Antagonist 17 has shown the ability to suppress tumor growth in LNCaP xenografts without noticeable toxicity. This reagent serves as a valuable tool for investigations into CRPC mechanisms and potential therapeutic strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
