Product Data Sheet
FL442
Catalog No. A85053
FL442 is an androgen receptor (AR) modulator that demonstrates potent inhibitory effects in AR-dependent prostate cancer cells. It exhibits comparable efficacy to traditional antiandrogen therapies while retaining activity against the AR mutant F876L, known for its resistance to standard treatments. Pharmacokinetic studies in mice reveal a long half-life of 8 hours, favorable targeting of prostate tissue, and metabolic stability. FL442 effectively inhibits LNCaP tumor growth at low plasma concentrations, positioning it as a valuable tool for research in prostate cancer therapeutics.
Chemical Information
| Catalog Num | A85053 |
|---|---|
| M. Wt | 294.27 |
| Formula | C15H13F3N2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1431166-12-9 |
| Synonyms | |
| SMILES | N#CC1=C(C(F)(F)F)C=C(C2=NOC3CCCCC23)C=C1 |
Biological Activity
| Description | FL442 is an androgen receptor (AR) modulator that demonstrates potent inhibitory effects in AR-dependent prostate cancer cells. It exhibits comparable efficacy to traditional antiandrogen therapies while retaining activity against the AR mutant F876L, known for its resistance to standard treatments. Pharmacokinetic studies in mice reveal a long half-life of 8 hours, favorable targeting of prostate tissue, and metabolic stability. FL442 effectively inhibits LNCaP tumor growth at low plasma concentrations, positioning it as a valuable tool for research in prostate cancer therapeutics. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
