Product Data Sheet
Y134
Catalog No. A85116
Y134 is a selective estrogen receptor modulator (SERM) that exhibits significant antagonist activity against both ERα and ERβ. With a remarkable 121.1-fold selectivity for ERα (Ki=0.09 nM) compared to ERβ (Ki=11.31 nM), Y134 effectively inhibits estrogen-stimulated proliferation in ER-positive human breast cancer cells. This compound is valuable for research applications focused on breast cancer biology and the modulation of estrogenic signaling pathways.
Chemical Information
| Catalog Num | A85116 |
|---|---|
| M. Wt | 472.60 |
| Formula | C28H28N2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 849662-80-2 |
| Synonyms | |
| SMILES | O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(N5CCN(C(C)C)CC5)C=C4 |
Biological Activity
| Description | Y134 is a selective estrogen receptor modulator (SERM) that exhibits significant antagonist activity against both ERα and ERβ. With a remarkable 121.1-fold selectivity for ERα (Ki=0.09 nM) compared to ERβ (Ki=11.31 nM), Y134 effectively inhibits estrogen-stimulated proliferation in ER-positive human breast cancer cells. This compound is valuable for research applications focused on breast cancer biology and the modulation of estrogenic signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
