Product Data Sheet
GNE-274
Catalog No. A85129
GNE-274 is a selective partial estrogen receptor (ER) agonist that enhances the chromatin accessibility of ER-DNA binding sites, distinguishing it from traditional ER degrader compounds. This compound functions by inhibiting the ligand-binding domain (LBD) of ER, making it a valuable tool in breast cancer research. GNE-274 offers insights into ER signaling pathways and can be instrumental in studies investigating ER-mediated gene regulation and cancer progression.
Chemical Information
| Catalog Num | A85129 |
|---|---|
| M. Wt | 457.56 |
| Formula | C29H31NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2369048-69-9 |
| Synonyms | |
| SMILES | CCCN1CC(C1)COC2=CC=C([C@@H]3OC4=CC=C(C=C4C(C)=C3C5=CC(O)=CC=C5)O)C=C2 |
Biological Activity
| Description | GNE-274 is a selective partial estrogen receptor (ER) agonist that enhances the chromatin accessibility of ER-DNA binding sites, distinguishing it from traditional ER degrader compounds. This compound functions by inhibiting the ligand-binding domain (LBD) of ER, making it a valuable tool in breast cancer research. GNE-274 offers insights into ER signaling pathways and can be instrumental in studies investigating ER-mediated gene regulation and cancer progression. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
