Product Data Sheet
ERα degrader-2
Catalog No. A85144
ERα degrader-2 is a selective estrogen receptor degrader (SERD) that exhibits potent binding affinity for the estrogen receptor alpha (ERα) with an IC50 of 17.1 nM and demonstrates robust degradation efficacy with an EC50 of 0.3 nM. This compound possesses favorable pharmacokinetic properties, making it a valuable tool for studying HER2-positive breast cancer. ERα degrader-2 is suitable for applications in cancer research, particularly in investigating therapeutic strategies targeting ERα signaling pathways.
Chemical Information
| Catalog Num | A85144 |
|---|---|
| M. Wt | 492.53 |
| Formula | C29H27F3N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2235396-63-9 |
| Synonyms | |
| SMILES | CC(C)(F)CN1[C@@](C2=C(C=C(C3=CC=C(C=C3)C(O)=O)C=C2F)F)([H])C4=C(C[C@H]1C)C5=CC=CC=C5N4 |
Biological Activity
| Description | ERα degrader-2 is a selective estrogen receptor degrader (SERD) that exhibits potent binding affinity for the estrogen receptor alpha (ERα) with an IC50 of 17.1 nM and demonstrates robust degradation efficacy with an EC50 of 0.3 nM. This compound possesses favorable pharmacokinetic properties, making it a valuable tool for studying HER2-positive breast cancer. ERα degrader-2 is suitable for applications in cancer research, particularly in investigating therapeutic strategies targeting ERα signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
