Product Data Sheet
LNS8801
Catalog No. A85145
LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). This compound facilitates the activation of downstream signaling pathways, notably enhancing the production of cyclic adenosine monophosphate (cAMP) and stimulating the cAMP response element-binding protein (CREB) pathway. LNS8801 demonstrates anti-tumor properties, including the inhibition of tumor cell proliferation, induction of cell differentiation, and enhancement of tumor immunogenicity. Its research applications are relevant across various cancer types, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as investigations into the physiological and pathological roles of GPER.
Chemical Information
| Catalog Num | A85145 |
|---|---|
| M. Wt | 412.28 |
| Formula | C21H18BrNO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 925419-55-2 |
| Synonyms | |
| SMILES | BrC(C([C@@]1([H])NC(C=CC(C(C)=O)=C2)=C2[C@]3([H])[C@@]1([H])CC=C3)=C4)=CC5=C4OCO5 |
Biological Activity
| Description | LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). This compound facilitates the activation of downstream signaling pathways, notably enhancing the production of cyclic adenosine monophosphate (cAMP) and stimulating the cAMP response element-binding protein (CREB) pathway. LNS8801 demonstrates anti-tumor properties, including the inhibition of tumor cell proliferation, induction of cell differentiation, and enhancement of tumor immunogenicity. Its research applications are relevant across various cancer types, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as investigations into the physiological and pathological roles of GPER. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
