Product Data Sheet
ZK164015
Catalog No. A85150
ZK164015 is an estrogen-glucocorticoid receptor chimera that primarily targets the estrogen receptor (ER). This compound serves as a valuable screening tool to assess tissue-selective estrogen activity and has been utilized to investigate ER function in osteoblasts. Studies involving osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cell lines demonstrated that ZK164015 modulates ERE-luciferase reporter activity and influences nuclear mobility, revealing its distinct effects in response to ER agonists.
Chemical Information
| Catalog Num | A85150 |
|---|---|
| M. Wt | 513.73 |
| Formula | C30H43NO4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 177583-70-9 |
| Synonyms | |
| SMILES | OC1=CC2=C(N(CCCCCCCCCCS(=O)(CCCCC)=O)C(C3=CC=C(O)C=C3)=C2C)C=C1 |
Biological Activity
| Description | ZK164015 is an estrogen-glucocorticoid receptor chimera that primarily targets the estrogen receptor (ER). This compound serves as a valuable screening tool to assess tissue-selective estrogen activity and has been utilized to investigate ER function in osteoblasts. Studies involving osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cell lines demonstrated that ZK164015 modulates ERE-luciferase reporter activity and influences nuclear mobility, revealing its distinct effects in response to ER agonists. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
