Product Data Sheet
Acolbifene hydrochloride
Catalog No. A85160
Acolbifene hydrochloride is a selective estrogen receptor modulator (SERM) that acts as an estrogen receptor antagonist. It effectively inhibits estradiol (E2)-induced transcriptional activity of the estrogen receptors ERα and ERβ, with IC50 values of 2 nM and 0.4 nM, respectively. This compound demonstrates strong antiestrogenic activity in both the mammary gland and uterus, highlighting its potential in cancer prevention research and exploration of anticarcinogenic properties.
Chemical Information
| Catalog Num | A85160 |
|---|---|
| M. Wt | 494.02 |
| Formula | C29H32ClNO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 252555-01-4 |
| Synonyms | EM-652 hydrochloride; SCH 57068 hydrochloride |
| SMILES | OC1=CC=C2C(C)=C(C3=CC=C(O)C=C3)[C@H](C4=CC=C(OCCN5CCCCC5)C=C4)OC2=C1.[H]Cl |
Biological Activity
| Description | Acolbifene hydrochloride is a selective estrogen receptor modulator (SERM) that acts as an estrogen receptor antagonist. It effectively inhibits estradiol (E2)-induced transcriptional activity of the estrogen receptors ERα and ERβ, with IC50 values of 2 nM and 0.4 nM, respectively. This compound demonstrates strong antiestrogenic activity in both the mammary gland and uterus, highlighting its potential in cancer prevention research and exploration of anticarcinogenic properties. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
