Product Data Sheet
ADX68692
Catalog No. A85208
ADX68692 is a selective negative allosteric modulator of the follicle-stimulating hormone (FSH) receptor, exhibiting a log IC50 of -5.71. This compound effectively inhibits hCG-induced cAMP production and β-arrestin 2 recruitment in HEK293 cells. ADX68692 demonstrates partial efficacy in mLTC-1 and primary rat Leydig cells, leading to reduced FSHR-mediated cAMP, progesterone, and estradiol production. Additionally, it has been shown to decrease the number of oocytes recovered from the ampullae, making it a valuable tool for studying reproductive biology and hormonal regulation.
Chemical Information
| Catalog Num | A85208 |
|---|---|
| M. Wt | 401.46 |
| Formula | C24H23N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1067191-08-5 |
| Synonyms | |
| SMILES | CC(C(C(C1=CN=CC=C1)=C2)=CC=C2NC(C3=CC=C(OC)C(OC)=C3)=O)(C#N)C |
Biological Activity
| Description | ADX68692 is a selective negative allosteric modulator of the follicle-stimulating hormone (FSH) receptor, exhibiting a log IC50 of -5.71. This compound effectively inhibits hCG-induced cAMP production and β-arrestin 2 recruitment in HEK293 cells. ADX68692 demonstrates partial efficacy in mLTC-1 and primary rat Leydig cells, leading to reduced FSHR-mediated cAMP, progesterone, and estradiol production. Additionally, it has been shown to decrease the number of oocytes recovered from the ampullae, making it a valuable tool for studying reproductive biology and hormonal regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
