Product Data Sheet
RU-39411
Catalog No. A85210
RU-39411 is a steroidal anti-estrogen that targets the estrogen receptor (ERR) with mixed estrogenic and antiestrogenic properties. It demonstrates significant inhibitory effects on cell proliferation in the MCF-7 breast cancer model, linked to its binding affinity for the estrogen receptor. RU-39411 effectively downregulates the estrogen binding capacity in cells without altering estrogen receptor mRNA levels, suggesting that the incorporation of its side chain modifies typical steroidal estrogen antagonist behavior. Additionally, RU-39411 promotes the synthesis of progesterone receptors, supporting its role as an active estrogen.
Chemical Information
| Catalog Num | A85210 |
|---|---|
| M. Wt | 435.60 |
| Formula | C28H37NO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 120382-04-9 |
| Synonyms | |
| SMILES | C[C@@]12[C@H](CC[C@]1([C@@]3(CCC4=C([C@]3([C@H](C2)C5=CC=C(C=C5)OCCN(C)C)[H])C=CC(O)=C4)[H])[H])O |
Biological Activity
| Description | RU-39411 is a steroidal anti-estrogen that targets the estrogen receptor (ERR) with mixed estrogenic and antiestrogenic properties. It demonstrates significant inhibitory effects on cell proliferation in the MCF-7 breast cancer model, linked to its binding affinity for the estrogen receptor. RU-39411 effectively downregulates the estrogen binding capacity in cells without altering estrogen receptor mRNA levels, suggesting that the incorporation of its side chain modifies typical steroidal estrogen antagonist behavior. Additionally, RU-39411 promotes the synthesis of progesterone receptors, supporting its role as an active estrogen. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
