Product Data Sheet
ER degrader 12
Catalog No. A85218
ER Degrader 12 is an estrogen receptor (ER) degrader with demonstrated IC50 values of 2.3 nM for ERα and 80.2 nM for ERβ, as shown in TR-FRET assays. This compound effectively inhibits the proliferation of MCF-7 breast cancer cells, exhibiting an IC50 of 1.53 nM. ER Degrader 12 is primarily utilized in research applications focused on understanding breast cancer biology and therapeutic strategies targeting estrogen signaling pathways.
Chemical Information
| Catalog Num | A85218 |
|---|---|
| M. Wt | 487.56 |
| Formula | C26H32F3N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2376991-14-7 |
| Synonyms | |
| SMILES | FC1=C(C2C3=C(CC(C)N2CC(C)C)C4=C(N=NN4)C=C3)C(F)=CC(OCCN5CC(C5)CF)=C1 |
Biological Activity
| Description | ER Degrader 12 is an estrogen receptor (ER) degrader with demonstrated IC50 values of 2.3 nM for ERα and 80.2 nM for ERβ, as shown in TR-FRET assays. This compound effectively inhibits the proliferation of MCF-7 breast cancer cells, exhibiting an IC50 of 1.53 nM. ER Degrader 12 is primarily utilized in research applications focused on understanding breast cancer biology and therapeutic strategies targeting estrogen signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
