Product Data Sheet
Raloxifene 4'-glucuronide-d4
Catalog No. A85228
Raloxifene 4'-glucuronide-d4 is a deuterated stable isotope of Raloxifene 4'-glucuronide, a primary metabolite of Raloxifene. This compound is primarily formed through the action of UGT1A10 and UGT1A8 enzymes. Raloxifene 4'-glucuronide exhibits binding to the estrogen receptor with an IC50 of 370 μM. It functions as a selective estrogen receptor modulator, activating the TGFβ3 promoter as a full agonist at nanomolar concentrations while also inhibiting expression from the estrogen response element-containing vitellogenin promoter. This makes it a valuable tool for studying estrogen receptor activity and metabolism in chemical research.
Chemical Information
| Catalog Num | A85228 |
|---|---|
| M. Wt | 653.73 |
| Formula | C34H31D4NO10S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1279033-52-1 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(C=C1)OC([2H])([2H])C([2H])([2H])N2CCCCC2)C3=C(C4=CC=C(C=C4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)C(O)=O)SC6=CC(O)=CC=C63 |
Biological Activity
| Description | Raloxifene 4'-glucuronide-d4 is a deuterated stable isotope of Raloxifene 4'-glucuronide, a primary metabolite of Raloxifene. This compound is primarily formed through the action of UGT1A10 and UGT1A8 enzymes. Raloxifene 4'-glucuronide exhibits binding to the estrogen receptor with an IC50 of 370 μM. It functions as a selective estrogen receptor modulator, activating the TGFβ3 promoter as a full agonist at nanomolar concentrations while also inhibiting expression from the estrogen response element-containing vitellogenin promoter. This makes it a valuable tool for studying estrogen receptor activity and metabolism in chemical research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
