Product Data Sheet
LX-039
Catalog No. A85245
LX-039 is a potent and selective estrogen receptor degrader with an EC50 value of 2.29 nM. Featuring an indole C-3 chlorine substituent, LX-039 demonstrates favorable pharmacokinetics in mouse models, characterized by low clearance and high maximum concentration (Cmax) following oral administration. Its efficacy in degrading estrogen receptors highlights its potential for anti-tumor applications in research settings.
Chemical Information
| Catalog Num | A85245 |
|---|---|
| M. Wt | 480.36 |
| Formula | C27H20Cl2FNO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2135341-09-0 |
| Synonyms | |
| SMILES | O=C(O)/C=C/C1=CC=C(/C(C(N2)=C(Cl)C3=C2C=CC=C3)=C(C4=CC=C(F)C=C4Cl)\CC)C=C1 |
Biological Activity
| Description | LX-039 is a potent and selective estrogen receptor degrader with an EC50 value of 2.29 nM. Featuring an indole C-3 chlorine substituent, LX-039 demonstrates favorable pharmacokinetics in mouse models, characterized by low clearance and high maximum concentration (Cmax) following oral administration. Its efficacy in degrading estrogen receptors highlights its potential for anti-tumor applications in research settings. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
