Product Data Sheet
ent-Estradiol
Catalog No. A85285
Ent-Estradiol is a selective ligand for the estrogen receptors, specifically targeting both ERα and ERβ. As the enantiomer of 17β-Estradiol, it exhibits minimal estrogenic activity, making it valuable for studies that require the modulation of estrogen receptors without significant hormonal effects. Ent-Estradiol demonstrates varying inhibitory concentrations with IC50 values of 24.9 nM, 9.59 nM, and 8.17 nM for human, rat, and mouse ERβ, respectively, and 151 nM, 246 nM, and 268 nM for ERα across the same species. This compound is instrumental in researching menopausal physiological changes and receptor-specific mechanisms.
Chemical Information
| Catalog Num | A85285 |
|---|---|
| M. Wt | 272.38 |
| Formula | C18H24O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3736-22-9 |
| Synonyms | ent-β-Estradiol; ent-17β-Estradiol; ent-17β-Oestradiol |
| SMILES | C[C@]12[C@@](CC[C@H]2O)([H])[C@]3([H])[C@](CC1)([H])C4=CC=C(O)C=C4CC3 |
Biological Activity
| Description | Ent-Estradiol is a selective ligand for the estrogen receptors, specifically targeting both ERα and ERβ. As the enantiomer of 17β-Estradiol, it exhibits minimal estrogenic activity, making it valuable for studies that require the modulation of estrogen receptors without significant hormonal effects. Ent-Estradiol demonstrates varying inhibitory concentrations with IC50 values of 24.9 nM, 9.59 nM, and 8.17 nM for human, rat, and mouse ERβ, respectively, and 151 nM, 246 nM, and 268 nM for ERα across the same species. This compound is instrumental in researching menopausal physiological changes and receptor-specific mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
