Product Data Sheet
(1S,3R)-GNE-502
Catalog No. A85287
(1S,3R)-GNE-502 is a selective estrogen receptor alpha (ERα) degrader, exhibiting a potent EC50 of 13 nM in MCF7 human breast cancer cells. This compound effectively downregulates ERα levels, making it a valuable tool for investigating estrogen-mediated signaling pathways in cancer research. Its application extends to exploring therapeutic strategies for ERα-positive breast cancer and understanding the biological mechanisms underlying estrogen receptor regulation.
Chemical Information
| Catalog Num | A85287 |
|---|---|
| M. Wt | 471.59 |
| Formula | C25H30FN3O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1953134-15-0 |
| Synonyms | |
| SMILES | C[C@@H]1CC(C2=CC=CC=C2N3)=C3[C@H](C4=CC=C(C=C4)OCCN5CC(C5)CF)N1S(=O)(C)=O |
Biological Activity
| Description | (1S,3R)-GNE-502 is a selective estrogen receptor alpha (ERα) degrader, exhibiting a potent EC50 of 13 nM in MCF7 human breast cancer cells. This compound effectively downregulates ERα levels, making it a valuable tool for investigating estrogen-mediated signaling pathways in cancer research. Its application extends to exploring therapeutic strategies for ERα-positive breast cancer and understanding the biological mechanisms underlying estrogen receptor regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
