Product Data Sheet
Lactandrate
Catalog No. A85327
Lactandrate targets the estrogen receptor alpha (ERα) as a D-high nitrogen steroid alkylating agent. It exhibits a significant growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. In vivo studies have demonstrated its anti-tumor activity in mouse models of breast cancer, including MXT and CD8F1 strain tumors, as well as in human xenograft MX-1 models. Lactandrate serves as a valuable reagent for research in cancer biology, particularly in studying estrogen receptor modulation and breast cancer therapeutics.
Chemical Information
| Catalog Num | A85327 |
|---|---|
| M. Wt | 563.60 |
| Formula | C31H44Cl2N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 43000-65-3 |
| Synonyms | |
| SMILES | C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)OC(CC4=CC=C(C=C4)N(CCCl)CCCl)=O)([H])[C@@]5([H])[C@](CC3)(NC(CC5)=O)C |
Biological Activity
| Description | Lactandrate targets the estrogen receptor alpha (ERα) as a D-high nitrogen steroid alkylating agent. It exhibits a significant growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. In vivo studies have demonstrated its anti-tumor activity in mouse models of breast cancer, including MXT and CD8F1 strain tumors, as well as in human xenograft MX-1 models. Lactandrate serves as a valuable reagent for research in cancer biology, particularly in studying estrogen receptor modulation and breast cancer therapeutics. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
