Product Data Sheet
NH-3
Catalog No. A85432
NH-3 is a reversible antagonist of the thyroid hormone receptor (THR) with an IC50 of 55 nM. It effectively inhibits the binding of thyroid hormones to their receptor, consequently preventing cofactor recruitment. Additionally, NH-3 serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This compound is useful in studies related to thyroid function and receptor signaling pathways.
Chemical Information
| Catalog Num | A85432 |
|---|---|
| M. Wt | 473.52 |
| Formula | C28H27NO6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 447415-26-1 |
| Synonyms | |
| SMILES | O=C(O)COC1=CC(C)=C(CC2=CC(C#CC3=CC=C([N+]([O-])=O)C=C3)=C(O)C(C(C)C)=C2)C(C)=C1 |
Biological Activity
| Description | NH-3 is a reversible antagonist of the thyroid hormone receptor (THR) with an IC50 of 55 nM. It effectively inhibits the binding of thyroid hormones to their receptor, consequently preventing cofactor recruitment. Additionally, NH-3 serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This compound is useful in studies related to thyroid function and receptor signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
