Product Data Sheet
Thyroid hormone receptor antagonist (1-850)
Catalog No. A85442
Thyroid hormone receptor antagonist (1-850) is a competitive and selective antagonist targeting thyroid hormone receptors (TR) with an IC50 of 1.5 μM. This compound effectively inhibits T3-mediated interactions between TRα and TRβ with nuclear receptor coactivators. Thyroid hormone receptor antagonist (1-850) is suitable for research focused on thyroid hormone signaling pathways and their implications in various biological processes, while exhibiting no effect on retinoic acid receptor alpha (RARα) activity.
Chemical Information
| Catalog Num | A85442 |
|---|---|
| M. Wt | 463.41 |
| Formula | C21H20F3N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 251310-57-3 |
| Synonyms | |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1)NNC(/C=C2CCN(CC\2)C3=CC=C(C=C3)[N+]([O-])=O)=O |
Biological Activity
| Description | Thyroid hormone receptor antagonist (1-850) is a competitive and selective antagonist targeting thyroid hormone receptors (TR) with an IC50 of 1.5 μM. This compound effectively inhibits T3-mediated interactions between TRα and TRβ with nuclear receptor coactivators. Thyroid hormone receptor antagonist (1-850) is suitable for research focused on thyroid hormone signaling pathways and their implications in various biological processes, while exhibiting no effect on retinoic acid receptor alpha (RARα) activity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
