Product Data Sheet
TR antagonist 2
Catalog No. A85447
TR Antagonist 2 is a competitive antagonist of thyroid hormone receptors TRα and TRβ with an IC50 of 47 nM. By competing with triiodothyronine (T3) for binding to the ligand-binding domain, it disrupts receptor-coactivator complex formation, thereby inhibiting target gene transcription and reducing the hypermetabolic effects associated with thyroid hormones. This compound is valuable for research into conditions such as hyperthyroidism and thyrotoxicosis, providing insights into therapeutic strategies for these disorders.
Chemical Information
| Catalog Num | A85447 |
|---|---|
| M. Wt | 463.41 |
| Formula | C21H20F3N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1073179-55-1 |
| Synonyms | |
| SMILES | O=C(NC1=CC=CC(C(F)(F)F)=C1)NNC(CC2=CCN(CC2)C3=CC=C([N+]([O-])=O)C=C3)=O |
Biological Activity
| Description | TR Antagonist 2 is a competitive antagonist of thyroid hormone receptors TRα and TRβ with an IC50 of 47 nM. By competing with triiodothyronine (T3) for binding to the ligand-binding domain, it disrupts receptor-coactivator complex formation, thereby inhibiting target gene transcription and reducing the hypermetabolic effects associated with thyroid hormones. This compound is valuable for research into conditions such as hyperthyroidism and thyrotoxicosis, providing insights into therapeutic strategies for these disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
