Product Data Sheet
ZK159222
Catalog No. A85515
ZK159222 is a potent vitamin D receptor (VDR) antagonist, functioning as a 25-carboxylic ester derivative of 1α,25-(OH)2D3. Its mechanism of action involves preventing ligand-induced interactions between the vitamin D receptor and coactivators, thereby inhibiting the receptor's activity. ZK159222 also exhibits partial agonist characteristics, making it valuable for research into VDR signaling pathways and potential therapeutic applications in diseases related to vitamin D metabolism.
Chemical Information
| Catalog Num | A85515 |
|---|---|
| M. Wt | 512.72 |
| Formula | C32H48O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 156965-15-0 |
| Synonyms | |
| SMILES | O=C(C1([C@H](O)/C=C/[C@H]([C@H]2CC[C@@]3([H])/C(CCC[C@]23C)=C/C=C4C([C@@H](O)C[C@H](O)C\4)=C)C)CC1)OCCCC |
Biological Activity
| Description | ZK159222 is a potent vitamin D receptor (VDR) antagonist, functioning as a 25-carboxylic ester derivative of 1α,25-(OH)2D3. Its mechanism of action involves preventing ligand-induced interactions between the vitamin D receptor and coactivators, thereby inhibiting the receptor's activity. ZK159222 also exhibits partial agonist characteristics, making it valuable for research into VDR signaling pathways and potential therapeutic applications in diseases related to vitamin D metabolism. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
